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The latest blog posts to take off on Hacker News. 6,220 posts.

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2025
5380

Is Ketamine Neurotoxic?

It is clear that ketamine at a sufficient dose & frequency can and does kill neurons through NMDA-driven excitotoxicity. However, what does a sufficient dose & frequency mean? There is a common myth that ketamine is “neurogenetic”. This is mostly false. While it does increase neurogenesis in the only two places in the…

5387

Defragging my old Dell's UEFI NVRAM

I’m setting up an old Dell box (2011-era tech). I was migrating to some new boot drives and setting up grub on them again. Got to the point of deleting the old boot entries and adding new ones, and got an error like Could not prepare boot variable: No space left on device. Weird, because there weren’t that many EFI…

5397

Half-Life

Around twenty years ago, people would have laughed if you told them that videogames would end up at the Smithsonian, but the Half-Life team really did want to make games that were more than just throwaway toys. The rule against cinematics — which made our jobs much harder and also ended up leaving a lot of my favorite…

5400

Ask for no, don't ask for yes (2022)

I think it is important to have a bias for action. Like anything else, this is something you can make a habit of. Moving forward allows you to make progress. I don’t know about you, but I’ve frozen up in the past not knowing what the right path was for me. Moving forward, even the smallest possible step, helped break…