721
Antibody Drug Conjugates: A frontier in cancer treatment
Learn how antibody-drug conjugates work as a “magic bullet” cancer treatment, combining targeted antibodies with chemotherapy to attack tumor cells more precisely.
Top posts
Every blog post that took off on Hacker News, ranked by the votes of its best submission. 776 posts.
722
Databases in 2023: A Year in Review
Andy recounts the rise of vector databases to SQL:2023 to MariaDB troubles and the FAA outage in 2023.
723
724
The business of wallets
How digital wallets work, and how payment costs drive a lot of product decisions inside and around them.
725
726
727
The problem with lying is keeping track of all the lies
Or why clear consistency guarantees are how to stay sane when programming distributed systems.
728
Release of Fugaku-LLM – a large language model trained on supercomputer Fugaku
Release of “Fugaku-LLM” – a large language model trained on the supercomputer “Fugaku”
729
New Anti-Toxicity Features on Bluesky
Trust and Safety (T&S) affects everything — from community policy and spam detection, all the way to the order that replies show up on a post. At Bluesky, the product team works hand-in-hand with T&S to design features that balance safety, ease of use, and fun.
730
Solar will get too cheap to connect to the power grid
The cost of solar panels is plummeting, and this will flood the power grid with cheap electricity. But that’s just Act 1. We won’t stop building solar at the limits of the grid - we’ll build a lot more. This post explains why we'll keep building more,
731
OpenAI GPT-4 vs. Groq Mistral-8x7B
A few months ago, we ran a benchmark on a traditional parser and Mistral 7B (Open Source LLM). The quality of the parsed result from Mistral 7B is quite impressive given it is only 7B parameters. One thing we weren't satisfied with is the processing time. Recently, I stumbled
732
The Rise and Fall of Ashton-Tate (2023)
Vulcan & dBASE
733
Ancestry to paywall formerly free features included with DNA kit
Ancestry is in the process of revamping its DNA services with higher prices and new fees, including a new paid offering called AncestryDNA Plus that paywalls formerly free features. Here's what we know, and what you can do if you have ever purchased an AncestryDNA kit.
734
Platform Strategy and Its Discontents
Alex Russell on browsers, standards, and the process of progress.
735
Rare things become common at scale (2014)
Software doesn't scale through architecture and automation alone. New, more difficult problems appear that didn't exist before, causing new downstream consequences.
736
NextNav's Callous Land-Grab to Privatize 900 MHz
The 900 MHz band, a frequency range serving as a commons for all, is now at risk due to NextNav’s brazen attempt to privatize this shared resource. Left by the FCC for use by amateur radio operators, unlicensed consumer devices, and industrial, scientific, and medical equipment, this spectrum has...
737
Is "Rich Dad Poor Dad" a Fraud?
With my interest in personal finance, the headline Robert Kiyosaki, ‘Rich Dad Poor Dad’ Author, Says, ‘I Am a Billionaire in Debt’ — And Calls Dave Ramsey An Idiot For Encou…
738
739
740
Reflections on Luck and Skill from the Part Time Poker Grind
In the early hours of May 13th, 2024 and after about sixteen hours of play over two days, I achieved one of my poker dreams and outlasted 773 entrants in the RunGood Poker Series $800 No Limit Hold’em Main Event hosted at Graton Casino and Resort to claim the outright win and top prize of $85,780.
741
The Algorithm Behind Jim Simons's Success
Reflections on a Wall Street legend.
742
Has Llama-3 just killed proprietary AI models?
Meta's release of Llama 3.2 marks a turning point where open-source AI models match and even surpass proprietary models.
743
The asymmetry of nudges
Answering the age-old question: why do bad decisions happen to good companies?
744
How Mihoyo's monetization works
You open your favourite social media site. You see the same discussions come up again.
745
746
747
748
Linux Foundation launches an open source fork of Redis
Community maintainers, contributors, and users will continue collaborative development of an open source, in-memory data store under the new Valkey name.
749
How Shadow Banning Can Silently Shift Opinion Online
In a new study, Yale SOM’s Tauhid Zaman and Yen-Shao Chen show how a social media platform can shift users’ positions or increase overall polarization by selectively muting and amplifying posts in ways that appear neutral to an outside observer.
750
The Subprime AI Crisis
None of what I write in this newsletter is about sowing doubt or "hating," but a sober evaluation of where we are today and where we may end up on the current path. I believe that the artificial intelligence boom — which would be better described as a generative AI boom