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AlphaGenome: AI for better understanding the genome
Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.
Top posts
Every blog post that took off on Hacker News, ranked by the votes of its best submission. 80,817 posts.
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Private by Design: How We Built Firefox Sync
Firefox Sync by default protects all your synced data so Mozilla can’t read it. We built Sync this way because we put user privacy first. How it works is...
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The Little Printf
This text is a transcript of a presentation I have given on October 9, 2015, at the CityCode conference in Chicago. This content is also available in video , and as a PDF Document better suited for printing.
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Eigenvectors from eigenvalues
Peter Denton, Stephen Parke, Xining Zhang, and I have just uploaded to the arXiv the short unpublished note “Eigenvectors from eigenvalues”. This note gives two proofs of a general eige…
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Writing Is Thinking: Learning to Write with Confidence
Learning to write is learning to think, because writing is thinking. They are two peas in a powerful pod. This article goes over my writing process, focused on minimizing the activation energy to get started.
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Surely the crash of the US economy has to be soon
Last year I predicted there would be a significant (2008+) economic crash that year. The year is now 2026 and I was wrong. At the time my main argument was essentially this: The unemployment rate just follows these smooth curves, covid was an exception, and it was due to jump again. Not very scientific I […]
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I rebooted my social life
Some self-help for the New Year
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I built a progressive web app and published it in three app stores
Summary : Turning a web app into a Progressive Web App (PWA) and submitting it to 3 app stores requires about a month of work, a few hundred dollars, and lots of red tape.
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PayPal Freezes Mailpile Campaign Funds
[ Update: PayPal have unfrozen the account, for now at least. Thank you for your support!]
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Goodbye to the C++ Implementation of Zig
It’s funny - I have shared this story a handful of times with friends of mine who are qualified, competent software engineers, and each time the response was confusion about why any of this would be necessary or even remotely helpful. WebAssembly ?!
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The Overcomplexity of the Shadcn Radio Button
Radio buttons are built into web browsers. Why are we using a UI library that wraps another UI library that rebuilds radio buttons from scratch? Why does rendering a radio button require multiple dependencies and several kilobytes of JavaScript? How did we make a built-in browser control so complicated?
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Lobbying is corruption
On lobbying, corruption, and the same animal under two names
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macOS Nix setup: an alternative to Homebrew (2020)
I recently got a new Macbook, and began setting up the Nix package manager to install my developer toolset. I mainly did this to try and have a working setup without installing Homebrew. Since I ran into a few issues, I wanted to briefly document what I did and why in case others wanted to try the same. Why Nix? (and…
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Firefox 67.0 Released
We'd like to extend a special thank you to all of the new Mozillians who contributed to this release of Firefox!
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The April Fools joke that might have got me fired
Everyone should pull one great practical joke in their lifetimes. This one was mine, and I think it's past the statute of limitations. The s...
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D Language accepted for inclusion in GCC
This is the mail archive of the gcc@gcc.gnu.org mailing list for the GCC project .
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Reverse engineering Call of Duty anti-cheat
Interested in Anti-Cheat analysis? I highly recommend checking out Guided Hacking’s Anti-Cheat section. I’ve been reversing Black Ops Cold War for a while now, and I’ve finally decided to share my research regarding the user-mode anti-cheat inside the game. It’s not my intention to shame or promote cheating/bypassing…
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Gravitational waves from a binary black hole merger observed by LIGO and Virgo
The LIGO Scientific Collaboration and the Virgo collaboration report the first joint detection of gravitational waves with both the LIGO and Virgo detectors. This is the fourth announced detection of a binary black hole system and the first significant gravitational-wave signal recorded by the Virgo detector, and…
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How Quake.exe got its TCP/IP stack
Released in June 1996, Quake had to ride three technological shock-waves during its lifetime. Besides the emergence of 3D hardware accelerator cards and the growth of the Internet, an operating system shift put game developers in a tough position.
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Keeping secrecy the exception, not the rule
This morning we filed a new lawsuit in federal court against the United States government to stand up for what we believe are our customers’ constitutional and fundamental rights – rights that help protect privacy and promote free expression. This is not a decision we made lightly, and hence we wanted to share…
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Issues with Cloudflare Images
Status: 5/9 fixed I’m a huge fan of the various Cloudflare offerings, and have been impressed time after time with the innovations and solutions offered by CF. This writeup therefore pains me, as I usually don’t have anything negative to say about CF, but after some months in production, and a severe lack of any…
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The Internet Is a Surveillance State
Polish translation I’m going to start with three data points. One: Some of the Chinese military hackers who were implicated in a broad set of attacks against the U.S. government and corporations were identified because they accessed Facebook from the same network infrastructure they used to carry out their attacks…