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The Sloppification of Peptides
Nobody in the comments is real
New
The latest blog posts to take off on Hacker News. 80,794 posts.
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Tragically, as many as 9625 out of every 10k individuals may be neurotypical
Neurotypical syndrome is a neurobiological disorder characterized by preoccupation with social concerns, delusions of superiority, and obsession with conformity.
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JIT Compiling Code in 5μs
Build a copy-and-patch JIT compiler in Rust, generate ARM64 machine code, and benchmark it against an interpreter and handwritten implementation.
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The End of an Athlon
When I was researching the mess related to strange and poorly documented CPUID bits in the Athlon MP and XP processors , I had to swap a lot of CPUs. This was uneventful in most cases… but only most.
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Fast and Hard Code
People pick languages differently with LLMs.
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To become a better writer, read as much as you can
I’m obsessed with the craft of writing. I write every day, I read about the craft often, and in my...
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I dream of quieter computing
A quick note about future of computing and indieweb. It's about a 2 minute read.
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AI Chip Architectures
A look at AI Chip Architectures. NVIDIA, AMD, TPUs, Trainium, Groq, Cerebras.
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NanoGPT Speedrun Frontier
Compare 153 autonomous runs from 18 frontier models on the nanoGPT optimizer speedrun.
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hdiutil is deprecated in macOS 27 Golden Gate
The macOS command-line tool hdiutil is used to manipulate disk images. From the WHAT'S NEW section of man hdiutil on the latest macOS 27 Golden Gate beta:
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Things I want in a modern relational query language
This was a very old draft I’ve had sitting around for years. The recent discussions of new query languages like Acadia spurred me to revisit, revise, and publish this. I think one of the biggest causes of NoSQL is that… Continue reading →
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New MCP Roadmap
An update on the Model Context Protocol roadmap and focus areas for upcoming specification releases.
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A Kantian Critique of "Sorry" by Justin Bieber
Justin Bieber's "Sorry" is a song about regret, asking for forgiveness, and wanting another chance after having hurt someone. But philosophically speaking, what exactly makes an apology morally meaningful?
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There's no reason for software to be slow anymore
The other day, I saw a viral tweet saying that people talking about how LLMs are causing slow, bloated, code are going to eat crow once they re-write everything in super-optimized assembly. We're not quite at the point where we want to write everything in assembly , but some variant of what Nolan Lawson said about…
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Three important steps in my maturation process
My father passed recently, and he was twice my age. I am approximately the same age that he was when I was born, and I am now “the old generation” - there’s no one left in the generation above me.
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Rust Glancer: Rust LSP using 100x less RAM
Rust LSP that doesn't eat memory for breakfast
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A week of using Codex more than Claude
Claude goes above and beyond what is asked and guesses what you might want. Codex does what you tell it and stops at the first sign that it might be done. Ten impressions from a week of using Codex more.
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One night in Uzbekistan: Why was this one data point so influential?
We have a comment coming out in Nature next week that is going to cause the retraction of a high-profile paper by Kotz et al. from last year (the second most cited climate paper in the news in 2024).
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OTel isn’t going well
For years now one of the most reliable complaints I hear when I try to drag a team off their vendor specific SDK and onto OpenTelemetry is some variation of: "why does it seem like this isn't done yet?" Vendor SDKs for observability are, to put it charitably, idiot-
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Building an (almost) fully self-hosted, sandboxed, agentic software factory
I built an (almost) fully self-hosted, sandboxed, agentic software factory.
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What happens when a GPU reads memory
Following an LDG.E SASS instruction through the hardware units in an RTX 4090.
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Omacom Foundation launches with $8M
It’s time to dream big. Omarchy Quattro has given people a chance to experience what the malleable computer of the future looks like, and they like it (a lot!). It now feels like a moral obligation to make this future…
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I Just Want to Search
Learning to search was a key skill growing up as a teen in the 2000s. How to use accurate keywords, quotes, the entire lot of search operators. Google-fu was a hard earned skill (yes, I read a book) and helped me figure out a surprising amount of life.
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How we made a text-to-speech model respond in sub-50 ms
10 RPS with p95 TTFA under 50 ms on a single H100: how we optimized Qwen3-TTS serving.
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I ran Photoshop on a £0.60 computer chip
Colin's things that might be useful or interesting2026154 points49 commentsHardware & Electronics details
I've always had a fascination with simpler and low power computing. This lead me to run Photoshop on a 60 pence computer chip and it amazes me that this is possible.
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Zig’s Io.Threaded is neat
std.Io.Threaded is one of the implementations of Zig's new Io interface that enables concurrency. This is a boring just use threads impl. I personally find it neat though --- it does this weird thing that I wanted to do for ages, that to my knowledge no one else is doing properly, and implements it better than I…
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Kagi added a setting for removing paywalled links from search results
Better search results with no ads. Welcome to Kagi (pronounced kah-gee), a paid search engine that gives power back to the user.