Zebrafish protein unlocks dormant genes for heart repair
Researchers from the Bakkers group at the Hubrecht Institute have successfully repaired damaged mouse hearts using a protein from zebrafish.
The latest blog posts to take off on Hacker News. 6,220 posts.
Researchers from the Bakkers group at the Hubrecht Institute have successfully repaired damaged mouse hearts using a protein from zebrafish.
Perturbation and rescaling for efficient rendering of fractal images.
System76 built their first workstation-class Arm PC, the Thelio Astra, and it's marketed for streamlined autonomous vehicle development. But I'm not an automotive developer, just someone who enjoys Linux, Arm, and computing. So I was excited to spend a few weeks (which turned into a few months) testing the latest…
From GitHub Copilot to ChatGPT to Claude Artifacts, how Val Town borrowed the best of all the code generation tools
USB, the Universal Serial Bus, was first released in 1996. It did not achieve widespread adoption until some years later; for most of the '90s RS-232-ish serial and its awkward sibling the parallel port were the norm for external peripheral. It's sort of surprising that USB didn't take off faster, considering the…
Billions of people around the world use Google’s products every day, and they count on those products to work reliably. Behind the scenes, Google’s services have increased dramatically in scale over the last 25 years — and failures have become rarer even as the scale has grown. Google’s SRE team has pioneered methods…
Most coders want AI to write code faster: I want AI to write FASTER CODE.
B-Trees are not boring, after all
Explore the challenges of building a change data capture (CDC) pipeline for Postgres. And see how Sequin used a watermark design inspired by Netflix's DBLog.
Why owning your own domain and publishing on the open web beats renting attention from Reddit, Discord, Facebook, and other mega-concentrated platforms.
One of my weirder hobbies is trying to convince people that the idea that companies are listening to you through your phone’s microphone and serving you targeted ads is a …
Throughout the history of Free and Open Source software (FOSS), copyright assignment has simultaneously been controversial and accepted as the norm in our FOSS communities. This paradox, I believe, stems entirely from some key misunderstandings that perpetuate. This issue requires urgent discussion, as two of the most…
Apparently shlx is a “medium latency” (3 cycles) instruction on Alder Lake. My disappointment is immeasurable, and my day is ruined.
Life has been a haze this last year. After selling my company, I find myself in the totally un-relatable position of never having to work again. Everything feels like a side quest, but not in an inspiring way. I don’t have the same base desires driving me to make money or gain status. I have infinite freedom, yet I…
Some broadcast engineering tasks are a bit too daunting for me to consider. Climbing the massive towers that power radio and TV stations is one of them! Your browser does not support the video tag. Recently, local engineer Aaron Cox had the perfect set of conditions for a drone flight to capture some of that risk, as…
A blog by and for database architects.
Preserving and augmenting human insight in an age of automated knowledge with Zettelgarden
Kakizome, Japanese way of new-years resolution
Late last year, I started experiencing some unusual intermittent connection issues on my Desktop. In general, I had a stable connection with average latency; however, at (seemingly) random times throughout the week, I would start experiencing sudden 2000ms+ latency spikes every couple of seconds.
How Postgres’ v7 UUIDs are made monotonic, and why that’s a great feature.
It's easier than you think to write an exceptional software tutorial. You can stand out in a sea of mediocre guides by following a few simple rules.
Read about the new ebooks Standard Ebooks is releasing for Public Domain Day 2025!
blogs rot. wikis wait. 2025-01-01 wiki is my abyss is my wiki is my abyss is my wiki is my abyss is my wiki is my abyss is my wiki is my abyss is my wiki is my abyss is my wiki is my abyss is my wiki is my abyss is my wiki is my abyss is my wiki is my abyss is my wiki is my abyss is my wiki is my abyss is my wiki is…
This is the 25-year story of how I fell into the field of AI.
After spending part of my holiday building and deploying a new Rails 8 application, It's clearer than ever that Rails is awesome, and it's especially great f...
In this post I will talk about my favourite computer ergonomics hack, a DIY device I call "The Beeper".