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How to Build a Biotech
You’re intrigued by biotech and want to explore ideas in the area. Where do you start?
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The latest blog posts to take off on Hacker News. 1,552 posts.
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How I grew my Shopify micro-SaaS
11 key learnings and mistakes from our journey
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Must ride mule to and from work location
“David, this one, tell me about it …” He’d let me look at his domain name portfolio. Not names he owned and parked, but domains he owned & developed. This was another early project of his – a job board solely focused on the ranching industry. All aspects – cattle, outfitters, dude/guest, hunting, and even ... Read more
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Reflections on Being a Female Founder
Not a lot is written about being a female founder and CEO. I used to believe that my journey as a startup founder was the same as any other founder's experience, regardless of gender, in that it is...
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Researchers and Founders
I spent many years working with founders and now I work with researchers. Although there are always individual exceptions, on average it’s surprising to me how different the best people in these...
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Why I don’t usually meet startups in person (2019)
The other day, I tweeted. “Contrarian perspective here – it’s ok to *not* meet a founder in person before deciding to invest.” This set off a tweet firestorm — mostly …
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Launch an App
On May 14th, I launched Oh Bother — my first independent app in 7 years. I wrote a bit about my decision to build Oh Bother here, but now that my little app ...
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Idea Generation
The most common question prospective startup founders ask is how to get ideas for startups. The second most common question is if you have any ideas for their startup. But giving founders an idea...
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Lies, Damned Lies, and Stock-Based Compensation
Why many "profitable" public technology companies actually aren't
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Want to build a side business? buy a great domain name
[updated April, 2022] So you wanna start a side business while holding down a full-time job. Kool. Dang smart move – that’s the same route I took – ten years ago now. Self-funded, no VC to appease, no angel investor to update. Just you, and your sandbox of ambition. Hmm, but where to start? Which ... Read more
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I got my first $50/mo customer
Sharing everything I learn along the way and blog about my progress daily.
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Startup financial models – Templates compared for SaaS
Need a financial model for your startup? Fear not. I have extensively compared the top 12 templates, free and paid, so you don't have to do it.
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Signs that a business idea will probably fail
After 14 years running my own businesses, I’ve failed a lot. I haven’t kept count thankfully, but I’d say I’ve started at least 50 businesses / ideas and out of those, 3 have worked. And when I say worked I don’t mean staying in business, I mean resulting in either a decent income for me […]
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How to sell a B2B product
Lately, a bunch of early stage founders have emailed me to ask for go-to-market (GTM) advice. They have a real product, it solves a real problem for their handful of customers…
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Emotional debt in startups
Three to four years into my startup journey our then CTO Sunil introduced me to a term called “technical debt”. He explained that we would have to account some time to make changes to the product that won’t be seen by customers but that would support us in the long run. I was furious. How […]
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Tips for Founders Sales: Lessons from Starting Two B2B Startups
Thus far I’ve founded two bootstrapped B2B startups, and led sales on both. One is off to the races, profitable, and growing. We even hired a general manager so that I can free myself up to work on other projects. The other is slightly more nascent, and just barely at ramen profitability.
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Mistakes That Kill Startups (2006)
October 2006 In the Q & A period after a recent talk, someone asked what made startups fail. After standing there gaping for a few seconds I realized this was kind of a trick question. It's equivalent to asking how to make a startup succeed — if you avoid every cause of failure, you succeed — and that's too big a…
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How to Keep Your Company Alive – Observe, Orient, Decide and Act
This article previously appeared in the Harvard Business Review. It’s been updated with new information about the U.S. Paycheck Protection program and the Economic Injury Disaster Loan progra…
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Remote Work: Hiring, recruiting, and essential tools
This is the first part of a two part masterclass on remote work, now live here: 01:46 Meet Shogun, the e-commerce page builder 02:58 They started fully remote as a side project that became...
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How YC will be funding the S20 batch
Hint: it will involve a lot of video calls
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