Best of 2025

The blog posts Hacker News loved most in 2025. 992 posts.

Society, Policy & Culture
542

Is Ketamine Neurotoxic?

It is clear that ketamine at a sufficient dose & frequency can and does kill neurons through NMDA-driven excitotoxicity. However, what does a sufficient dose & frequency mean? There is a common myth that ketamine is “neurogenetic”. This is mostly false. While it does increase neurogenesis in the only two places in the…