Best of 2025

The blog posts Hacker News loved most in 2025. 6,220 posts.

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3256

The Simplicity of Prolog

Nowadays the most popular programming languages are Python, Javascript, Java, C++, C#, Kotlin and Ruby, and the average programmer is probably familiar with one or more of these languages. It's relatively easy to switch from one to another (barring any framework specific knowledge that may be needed), since they are…

3263

Angel Investors, a Field Guide

I’ve been lucky to work with some of the best angel investors in the business. When I started Akita, my angel investors were my mentor Jason Hong, superangel Elad Gil, #ANGELS co-founder Jana Messerschmidt, Eventbrite co-founders Kevin and Julia Hartz, Stanford professor Dan Boneh, and NBA player Kevin Durant. I…

3269

Is Ketamine Neurotoxic?

It is clear that ketamine at a sufficient dose & frequency can and does kill neurons through NMDA-driven excitotoxicity. However, what does a sufficient dose & frequency mean? There is a common myth that ketamine is “neurogenetic”. This is mostly false. While it does increase neurogenesis in the only two places in the…