Best of 2025

The blog posts Hacker News loved most in 2025. 202 posts.

Science & Space
97

Is Ketamine Neurotoxic?

It is clear that ketamine at a sufficient dose & frequency can and does kill neurons through NMDA-driven excitotoxicity. However, what does a sufficient dose & frequency mean? There is a common myth that ketamine is “neurogenetic”. This is mostly false. While it does increase neurogenesis in the only two places in the…

104

Why are smokestacks so tall?

[Note that this article is a transcript of the video embedded above.] “The big black stacks of the Illium Works of the Federal Apparatus Corporation spewed acid fumes and soot over the hundreds of men and women who were lined up before the red-brick employment office.” That’s the first line of one

105

It Awaits Your Experiments

You may have heard of Christian Bök. You may have read about him on this very blog if you’ve been hanging out here long enough. Perhaps you were even one of the very select few to witness the seminal talk I gave back in 2016 [1] —“ScArt: or, How to Tell When You’ve Finished Fucking”— which climaxed with a glowing…