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Science & Space

The most popular blog posts about science & space on Hacker News. 356 posts.

2026
182

The Computer at the Bottom of a Canal

Somewhere at the bottom of the Forth and Clyde Canal, buried in the silt, there is a box of custom silicon that was right about almost everything. Back in 1988 a Scottish hi-fi company shipped a processor that checked the type and bounds of every memory access in hardware, garbage-collected its own heap in silicon, […]

190

An idiot’s guide to lead optimisation for proteins

Lead optimisation is the step in drug design where you take a molecule that sort of works and try to make it actually work, and it’s arguably the step where most real-world design campaigns succeed or die. Due to the influence of a couple of my pals , I have recently become interested in using machine learning to do…

204

The Economic Complexity of the Western Roman Empire

I am one of those people who think about the Roman Empire daily – possibly out of my worrying addiction to Crusader Kings III and similar games. I also spent some time working on estimating economic complexity , a neat measure that can be used to explain economic development trajectories. One fateful day, I was…

206

How to grow a cacao tree at home (2024)

Growing chocolate at home might sound like a wild idea, right? Chocolate originates from cacao trees, which demand a tropical climate, specific growing conditions, and several years to reach maturity in order to flower and fruit to produce cacao pods. However, our CocoTerra founder, Nate Saal, took on the challenge…