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Every blog post that took off on Hacker News, ranked by the votes of its best submission. 4,109 posts.

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2025
2132

Angel Investors, a Field Guide

I’ve been lucky to work with some of the best angel investors in the business. When I started Akita, my angel investors were my mentor Jason Hong, superangel Elad Gil, #ANGELS co-founder Jana Messerschmidt, Eventbrite co-founders Kevin and Julia Hartz, Stanford professor Dan Boneh, and NBA player Kevin Durant. I…

2137

Is Ketamine Neurotoxic?

It is clear that ketamine at a sufficient dose & frequency can and does kill neurons through NMDA-driven excitotoxicity. However, what does a sufficient dose & frequency mean? There is a common myth that ketamine is “neurogenetic”. This is mostly false. While it does increase neurogenesis in the only two places in the…

2145

Omnimax

In a previous life, I worked for a location-based entertainment company, part of a huge team of people developing a location for Las Vegas, Nevada. It was COVID, a rough time for location-based anything, and things were delayed more than usual. Coworkers paid a lot of attention to another upcoming Las Vegas…

2153

Test, don't just verify

AI-assisted mechnical proving companies are raising funds on billion dollar valuations , new people are trying proof assistants, overwhelmingly Lean, at unprecedented rates. Models achieve fascinating results in competitions previously considered to contain some of the hardest problems in the world, such as IMO, ICPC…

2155

A manager is not your best friend

As people become managers, it's quite common for their team members to want to commiserate with them. This is especially true for friendly, competent, reasonable-seeming managers – people want to commiserate with winners. But commiseration, especially with your direct reports, is organizational poison.