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Aging-related inflammation is not universal across human populations
Inflammation may not be a universal human experience, but a byproduct of industrialized lifestyles.
New
The latest blog posts to take off on Hacker News. 2,111 posts.
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Why email startups fail
Comprehensive analysis of email startup failures. Why most email companies fail, burn millions in VC funding, and shut down. Learn what actually works.
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The hidden JTAG in a Qualcomm/Snapdragon device’s USB port
Learn about JTAG and EUD
1174
Proton joins suit against Apple for practices that harm developers and consumers
Apple's anti-competitive App Store policies are gouging consumers, enabling censorship, and harming privacy-focused developers. We're joining a lawsuit to restore internet freedom.
1175
Nano-engineered thermoelectrics enable scalable, compressor-free cooling
Researchers at Johns Hopkins APL, in collaboration with Samsung Research, have unveiled a breakthrough in solid-state cooling technology, doubling the efficiency of today’s commercial systems. Driven by the Lab’s patented nano-engineered thin-film thermoelectric materials and devices, this innovation paves the way for…
1176
LetsEncrypt – Expiration Notification Service Has Ended
Since its inception, Let’s Encrypt has been sending expiration notification emails to subscribers that have provided an email address to us via the ACME API. This service ended on June 4, 2025. The decision to end the service is the result of the following factors: Over the past 10 years more and more of our…
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China Dominates 44% of Visible Fishing Activity Worldwide
A new Oceana analysis reveals the global scale of China’s visible fishing fleet
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Genetic code enables zebrafish to mend damaged organs
New research identifies the genes necessary for zebrafish to regenerate their hearts after damage—work that could ultimately impact the recovery of human patients after heart attacks.
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People Keep Inventing Prolly Trees
A novel data structure has been invented four times now, with three different names. We think that's a good sign.
1182
JavaScript Trademark Update
The Trademark Trial and Appeal Board has dismissed our fraud claim against Oracle. We disagree with this decision.
1183
Life of an inference request (vLLM V1): How LLMs are served efficiently at scale
vLLM is an open-source inference engine that serves large language models. We deploy vLLM across GPUs and load open weight models like Llama 4 into it. vLLM sits at the intersection of AI and systems programming, so we thought that diving into its details might interest our readers.
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Normalizing Flows Are Capable Generative Models
Normalizing Flows (NFs) are likelihood-based models for continuous inputs. They have demonstrated promising results on both density…
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Project Vend: Can Claude run a small shop? (And why does that matter?)
We let Claude run a small shop in the Anthropic office. Here's what happened.
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Qwen VLo: From “Understanding” the World to “Depicting” It
QWEN CHAT DISCORD Introduction The evolution of multimodal large models is continually pushing the boundaries of what we believe technology can achieve. From the initial QwenVL to the latest Qwen2.5 VL, we have made progress in enhancing the model’s ability to understand image content. Today, we are excited to…
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The Effect of Noise on Sleep
Using Apple Watch noise and sleep stages to quantify the effect of noise on sleep
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Biomolecular shifts occur in our 40s and 60s (2024)
Time marches on predictably, but biological aging is anything but constant, according to a new Stanford Medicine study.
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Kea 3.0, our first LTS version
ISC is excited to announce the release of Kea 3.0.0! This is a major release, and is the first Long-Term Support (LTS) version of Kea.
1190
Matrix v1.15
Matrix, the open protocol for secure decentralised communications
1191
Introducing Gemma 3n
Learn how to build with Gemma 3n, a mobile-first architecture, MatFormer technology, Per-Layer Embeddings, and new audio and vision encoders.
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FLUX.1 Kontext [Dev] – Open Weights for Image Editing
Up until today, all capable generative image editing models were only available as proprietary tools.
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AlphaGenome: AI for better understanding the genome
Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.
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Learnings from building AI agents
How cubic reduced noisy AI code review comments with reasoning logs, fewer tools, specialized agents, and evaluation before changes reached production.
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-2000 Lines of code (2004)
In early 1982, the Lisa software team was trying to buckle down for the big push to ship the software within the next six months. Some of the managers decided that it would be a good idea to track the progress of each individual engineer in terms of the amount of code that they wrote from week to week. They devised a…
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MCP in LM Studio
New in LM Studio 0.3.17: Model Context Protocol (MCP) Host support. Connect MCP servers to the app and use them with local models.
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Build and Host AI-Powered Apps with Claude – No Deployment Needed
Build and share AI-powered apps directly in Claude. Update: Now available on Team and Enterprise plans. (July 31, 2025) Update: Upload PDFs, images, and more into your artifact.
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Bot or human? Creating an invisible Turing test for the internet
Behavioral and cognitive patterns distinguish humans from bots. Explore interactive demos and a practical framework for invisible Proof of Human.
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Is Lovable getting monetization wrong?
The current (and future) monetization strategies of "Shopify for SaaS"
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Gemini CLI
Free and open source, Gemini CLI brings Gemini directly into developers’ terminals — with unmatched access for individuals.