1
Melatonin: Much More Than You Wanted to Know (2018)
[I am not a sleep specialist. Please consult with one before making any drastic changes or trying to treat anything serious.] Van Geiklswijk et al describe supplemental melatonin as “a chrono…
Scott Alexander
Thanks for bearing with me the past few months. My new blog is at https://astralcodexten.substack.com/ . I’ll try to have a less unwieldy domain name working soon.
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Visit slatestarcodex.com → RSS feedOn Hacker News Jun 2013 – Jan 2024
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2
Adderall Risks: Much More Than You Wanted to Know
[Previously in series: Antidepressant Pharmacogenomics: Much More Than You Wanted To Know; SSRIs: Much More Than You Wanted To Know, etc. This is all preliminary and you should not take it as a rea…
3
Birth Order Effects Exist and Are Strong
“Birth order” refers to whether a child is the oldest, second-oldest, youngest, etc. in their family. For a while, pop psychologists created a whole industry around telling people how t…
4
Against Against Pseudoaddiction
I. “Pseudoaddiction” is one of the standard beats every article on the opioid crisis has to hit. Pharma companies (the story goes) invented a concept called “pseudoaddiction”…
5
Toward a Predictive Theory of Depression
[Epistemic status: Total wild speculation] I. The predictive processing model offers compelling accounts of autism and schizophrenia. But Surfing Uncertainty and related sources I’ve read are…
6
Some people who take psychedelics continue hallucinating indefinitely
[Related to: Relaxed Beliefs Under Psychedelics And The Anarchic Brain, HPPD And The Specter Of Permanent Side Effects] I. Hallucinogen persisting perceptual disorder is a condition where people wh…
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Cancer Progress: Much More Than You Wanted To Know (2018)
Official statistics say we are winning the War on Cancer. Cancer incidence rates, mortality rates, and five-year-survival rates have generally been moving in the right direction over the past few d…
8
What Developmental Milestones Are You Missing?
[Epistemic status: Speculative. I can’t make this post less condescending and elitist, so if you don’t like condescending elitist things, this might not be for you.] Developmental psych…
9
Dissolving the Fermi Paradox
I’m late to posting this, but it’s important enough to be worth sharing anyway: Sandberg, Drexler, and Ord on Dissolving the Fermi Paradox. The Fermi Paradox asks: given the immense num…
10
The control group is out of control (2014)
I. Allan Crossman calls parapsychology the control group for science. That is, in let’s say a drug testing experiment, you give some people the drug and they recover. That doesn’t tell …
11
An Iron Curtain Has Descended Upon Psychopharmacology
Imagine if a chemist told you offhandedly that the Russians had different chemical elements than we did. Here in America, we use elements like lithium and silicon and bismuth. We have figured out l…
12
Book Review: The Body Keeps the Score
I. The Body Keeps The Score is a book about post-traumatic stress disorder. The author, Bessel van der Kolk, helped discover the condition and lobby for its inclusion in the DSM, and the brief fora…
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Nootropics Survey Results And Analysis
In case you are just joining us: nootropics are substances which purportedly improve mental functioning with relatively few side effects when used responsibility. Caffeine is a good example. It imp…
14
How To Use 23andMe Irresponsibly (2014)
As you might remember, the FDA stomped on 23andMe for using too many irresponsible genetic tests that purported to tell you things about yourself and your health with limited support. They eventual…
15
5-HTTLPR: A Pointed Review
In 1996, some researchers discovered that depressed people often had an unusual version of the serotonin transporter gene 5-HTTLPR. The study became a psychiatric sensation, getting thousands of ci…
16
Adult Neurogenesis – A Pointed Review
[I am not a neuroscientist and apologize in advance for any errors in this article. A recent study came out contradicting some of the claims mentioned here. See here for study, this comment for som…
17
Why Were Early Psychedelicists so Weird?
[Epistemic status: very speculative, asserted with only ~30% confidence. On the other hand, even though psychiatrists don’t really talk about this it’s possible other groups know this a…
18
GPT-2 as step toward general intelligence (2019)
A machine learning researcher writes me in response to yesterday’s post, saying:I still think GPT-2 is a brute-force statistical pattern matcher which blends up the internet and gives you bac…
19
Face Masks: Much More Than You Wanted to Know
There’s been recent controversy about the use of face masks for protection against coronavirus. Mainstream sources, including the CDC and most of the media say masks are likely useless and no…
20
Beware Isolated Demands For Rigor
I. From Identity, Personal Identity, and the Self by John Perry:”There is something about practical things that knocks us off our philosophical high horses. Perhaps Heraclitus really thought …
21
Book Review: The Secret Of Our Success
[Previously in sequence: Epistemic Learned Helplessness] I. “Culture is the secret of humanity’s success” sounds like the most vapid possible thesis. The Secret Of Our Success by …
22
Book Review: Origin Of Consciousness In The Breakdown Of The Bicameral Mind
I. Julian Jaynes’ The Origin Of Consciousness In The Breakdown Of The Bicameral Mind is a brilliant book, with only two minor flaws. First, that it purports to explains the origin of consciou…
23
Book Review: The Hungry Brain
[Content note: food, dieting, obesity] I. The Hungry Brain gives off a bit of a Malcolm Gladwell vibe, with its cutesy name and pop-neuroscience style. But don’t be fooled. Stephan Guyenet is…
24
Schizophrenia: No Smoking Gun
[Note: despite how some people are spinning this, tobacco is still really really bad and you should not smoke it] I. Schizophrenics smoke. A lot. Depending on the study, about 60-80% of schizophren…
25
California, Water You Doing?
[Epistemic status: Low confidence. I have found numbers and stared at them until they made sense to me, but I have no education in this area. Tell me if I’m wrong.] I. There has recently been…
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SSRIs: Much More Than You Wanted To Know
The claim that “SSRIs don’t work” or “SSRIs are mostly just placebo” is most commonly associated with Irving Kirsch, a man with the awesome job title of “Associa…
27
Cardiologists and Chinese Robbers
I. It takes a special sort of person to be a cardiologist. This is not always a good thing. You may have read about one or another of the “cardiologist caught falsifying test results and perf…
28
Gender Imbalances Are Mostly Not Due To Offensive Attitudes
[This post has mostly been replaced/supplanted with a more thorough analysis in Contra Grant On Exaggerated Differences] I. One idea that kept coming up in the comments to the thread on signal-boos…
29
Society Is Fixed, Biology Is Mutable
Today during an otherwise terrible lecture on ADHD I realized something important we get sort of backwards. There’s this stereotype that the Left believes that human characteristics are socia…
30
Beware The Man Of One Study
Aquinas famously said: beware the man of one book. I would add: beware the man of one study. For example, take medical research. Suppose a certain drug is weakly effective against a certain disease…