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Like many researchers, I find that frontier language models often refuse mundane biology questions on biosecurity grounds. Things have improved – before Anthropic released Fable, Claude Opus’s guardrails were comically strict. Guardrails remain erratic however, even for the same model release. And unfortunately the…

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Removing newlines in FASTA file increases ZSTD compression ratio by 10x

2025279 points113 comments Databases & Data details

First released with Zstandard 1.3.2 in 2017, the --long range match finder increases the compressor’s search window to at least 128MiB, improving deduplication inside large files. This optional feature had substantial performance overheads at launch, but various optimisations have since brought its performance within…